EDUCATION AND ACADEMIC DEGREES
Medical Degree. University of Athens. Grade “Excellent” 1979
Doctorate Degree. University of Patras. Grade “Excellent” 1987
Resident in Internal Medicine. Department of Internal Medicine. School of Medicine. University of Patras 1983-1987
Training in Infections. Clatterbridge NHS Hospital and Royal Liverpool University Hospital, UK, 1991-1992
NHS Consultant. Department of Internal Medicine. School of Medicine. University of Patras
Lecturer in Internal Medicine. School of Medicine. University of Patras 1988-1993
Assistant Professor of Internal Medicine. School of Medicine. University of Patras 1993-2000
Associate Professor of Internal Medicine. School of Medicine. University of Patras 2000-2004
Professor of Internal Medicine. School of Medicine. University of Patras 2004-today
President of School of Medicine. University of Patras (2009-2012)
Deputy President of the Foundation Council of the University of Patras
PROFESSIONAL EXPERIENCE
Group Chief of Department of Internal Medicine, Regional General Hospital of Patras 1987-2011
Honorary Senior Registrar in Clinical Microbiology, Clatterbridge NHS Hospital and Honorary Research Fellow, Royal Liverpool University Hospital 1991-1992
Chief of Infectious Diseases Section of the Department of Internal Medicine, Regional General Hospital of Patras 2004-2015
Scientific Director of Special Infectious Disease Unit, Regional General Hospital of Patras 2004-2020
Chief of the Department of Internal Medicine. School of Medicine. University of Patras 2011-2020
Chief of the Medical Sector. Regional General Hospital of Patras 2016-2018
Chief of Medical Service. Regional General Hospital of Patras 2018-2020
MEMBERSHIP IN SOCIETIES, EDITORIAL BOARDS OF JOURNALS
President of Hellenic Sepsis Study Group
Vice-President of the Hellenic Scientific Society for the Study and Treatment of AIDS
Vice-President of the Hellenic Society of Internists
Member of the Board of the Hellenic Society of Infections and of the Hellenic Society of Antimicrobial Therapy
Member of the Board of the Medical Society of Western Greece and Peloponnesus
Deputy President of the Editorial Board of Journal “Achaian Medicine”
RESEARCH PROGRAMS
Main Researcher in a large number of Clinical Trials in the field of infections, sepsis and COVID-19
Ongoing Clinical Trials with main researcher: Professor Ch. Gogos
- A RANDOMIZED CLINICAL TRIAL FOR ENHANCED TRAINED IMMUNE RESPONSES THROUGH BACILLUS CALMETTE-GUÉRIN VACCINATION TO PREVENT INFECTIONS ΒΥ COVID-19: THE ACTIVATE II TRIAL
EudraCT: 2020-02448-21 - suPAR-GUIDED ANAKINRA TREATMENT FOR VALIDATION OF THE RISK AND EARLY MANAGEMENT OF SEVERE RESPIRATORY FAILURE BY COVID-19: THE SAVE OPEN-LABEL, NON-RANDOMIZED SINGLE-ARM TRIAL
EudraCT: 2020-001466-11 - EFFICIENCY IN MANAGEMENT OF ORGAN DYSFUNCTION ASSOCIATED WITH INFECTION BY THE NOVEL SARS-CoV-2 VIRUS (COVID-19) THROUGH A PERSONALIZED IMMUNOTHERAPY APPROACH: THE ESCAPE CLINICAL TRIAL
EudraCT: 2020-001039-29 - A PHASE 3, RANDOMIZED, DOUBLE-BLIND, ACTIVE CONTROLLED STUDY TO COMPARE THE EFFICACY AND SAFETY OF RIDINILAZOLE (200 mg, bid) FOR 10 DAYS WITH VANCOMYCIN (125 mg, qib) FOR 10 DAYS IN THE TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION (CDI)
Protocol Number: C3601002
EudraCT: 2017-002742-68 - A PHASE 3 PROSPECTIVE, RANDOMIZED, MULTICENTER, OPEN-LABEL, CENTRAL ASSESOR BLINDED, PARALLEL GROUP, COMPARATIVE STUDY TO DETERMINE THE EFFICAC, SAFETY AND TOLERABILITY OF AZTREONAM-AVIBACTAM (ATM-AVI) ± METRONIDAZOLE (MTZ) VERSUS MEROPENEM±COLISTINMER±COL) FOR THE TREATMENT OF SERIOUS INFECTIONS DUE TO GRAM-NEGATIVE BACTERIA, INCLUDING METALLO-B-LACTAMASE (MBL) – PRODUCING MULTIDRUG RESISTANT PATHOGENS FOR WHICH THERE LIMITED OR NO TREATMENT OPTIONS.
Protocol Number: C3601002
EudraCT: 2017-002742-68 - A PROSPECTIVE, RANDOMIZED, OPEN-LABEL, COMPARATIVE STUDY TO ASSESS THE EFFICACY, SAFETY AND TOLERABILITY OF AZTREONAM-AVIBACTAM (ATM-AVI) AND BEST AVAILABLE THERAPY FOR THE TREATMENT OF SERIOUS INFECTIONS DUE TO MULTI-DRUG RESISTANT GRAM- NEGATIVE BACTERIA PRODUCING METALLO-Β-LACTAMASE (MBL)
Protocol Number: C3601009
EudraCT: 2017-04544-38 - REAL-WORLD OBSERVATIONAL STUDY OF ZAVICEFTA (REGISTERED) (CEFTAZIDIME-AVIBACTAM) TO CHARACTERIZE THE USE PATTERNS, EFFECTIVENESS AND SAFETY
Protocol Number: C3591031
NCT: 03923426 - MULTINATIONAL RETROSPECTIVE CHART REVIEW TO ASSESS THE CHARACTERISTICS, TREATMENT OUTCOMES AND RESOURCE USE AMONG ADULT PATIENTS HOSPITALIZED FOR COMMUNITY-ACQUIRED PNEUMONIA (CAP) OR COMPLICATED SKIN AND SOFT TISSUE INFECTIONS (cSSTI) TREATED WITH ZINFORO® (|CEFTAROLINE FOSAMIL) IN A USUAL CARE SETTING
Protocol Number: C2661041
NCT: 04198571
PUBLICATIONS
170 Publications in PubMed / 8100 citations
List of the 20 most recent publications
- Akinosoglou K, Paliogianni F, Spyridonidis A, Symeonidis A, Alexopoulos LG,
Ziazias D, Kouraklis-Symeonidis A, Marangos M, Gogos C. SARS-CoV-2 persistence
and non-protective immunity in infected haematological patients. Br J Haematol.
2020 Nov 20. doi: 10.1111/bjh.17212. Epub ahead of print. PMID: 33216364. - Akinosoglou K, Gogos A, Papageorgiou C, Angelopoulos E, Gogos C. Ketamine in
COVID-19 patients: Thinking out of the box. J Med Virol. 2020 Nov 20. doi:
10.1002/jmv.26681. Epub ahead of print. PMID: 33215721. - Akinosoglou K, Kapsokosta G, Mouktaroudi M, Rovina N, Kaldis V, Stefos A,
Kontogiorgi M, Giamarellos-Bourboulis E, Gogos C; Hellenic Sepsis Study Group.
Diabetes on sepsis outcomes in non-ICU patients: A cohort study and review of
the literature. J Diabetes Complications. 2020 Oct 9:107765. doi:
10.1016/j.jdiacomp.2020.107765. Epub ahead of print. PMID: 33187869. - Assimakopoulos SF, Emmanuil A, Tsimeka A, Chalkidi T, Marangos M, Gogos C.
Evidence for increased circulating procoagulant phospholipids in patients with
COVID-19 pneumonia and their prognostic role. Clin Chem Lab Med. 2020 Oct
28:/j/cclm.ahead-of-print/cclm-2020-1260/cclm-2020-1260.xml. doi:
10.1515/cclm-2020-1260. Epub ahead of print. PMID: 33112778. - Akinosoglou K, Gogos C. Severe COVID-19 and interleukin-6 receptor antagonist
tocilizumab: Some notes of concern. Respirology. 2020 Sep 20:10.1111/resp.13939.
doi: 10.1111/resp.13939. Epub ahead of print. PMID: 32954552; PMCID: PMC7537009. - Kostaki EG, Gova M, Adamis G, Xylomenos G, Chini M, Mangafas N, Lazanas M,
Metallidis S, Tsachouridou O, Papastamopoulos V, Chatzidimitriou D, Kakalou E,
Antoniadou A, Papadopoulos A, Psichogiou M, Basoulis D, Pilalas D, Papageorgiou
I, Paraskeva D, Chrysos G, Paparizos V, Kourkounti S, Sambatakou H, Bolanos V,
Sipsas NV, Lada M, Barbounakis E, Kantzilaki E, Panagopoulos P, Petrakis V,
Drimis S, Gogos C, Hatzakis A, Beloukas A, Skoura L, Paraskevis D. A Nationwide
Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in
Greece: Inference of the Molecular Transmission Clusters. Viruses. 2020 Oct
19;12(10):1183. doi: 10.3390/v12101183. PMID: 33086773; PMCID: PMC7589601. - Deftereos SG, Giannopoulos G, Vrachatis DA, Siasos GD, Giotaki SG,
Gargalianos P, Metallidis S, Sianos G, Baltagiannis S, Panagopoulos P,
Dolianitis K, Randou E, Syrigos K, Kotanidou A, Koulouris NG, Milionis H, Sipsas
N, Gogos C, Tsoukalas G, Olympios CD, Tsagalou E, Migdalis I, Gerakari S,
Angelidis C, Alexopoulos D, Davlouros P, Hahalis G, Kanonidis I, Katritsis D,
Kolettis T, Manolis AS, Michalis L, Naka KK, Pyrgakis VN, Toutouzas KP,
Triposkiadis F, Tsioufis K, Vavouranakis E, Martinèz-Dolz L, Reimers B,
Stefanini GG, Cleman M, Goudevenos J, Tsiodras S, Tousoulis D, Iliodromitis E,
Mehran R, Dangas G, Stefanadis C; GRECCO-19 investigators. Effect of Colchicine
vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in
Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized
Clinical Trial. JAMA Netw Open. 2020 Jun 1;3(6):e2013136. doi:
10.1001/jamanetworkopen.2020.13136. PMID: 32579195; PMCID: PMC7315286. - Akinosoglou K, Velissaris D, Ziazias D, Davoulos C, Tousis A, Tsiotsios K,
Kalogeropoulou C, Spyridonidis A, Marangos M, Fligkou F, Gogos C. Remdesivir and
tocilizumab: Mix or match. J Med Virol. 2020 Jun 3:10.1002/jmv.26117. doi:
10.1002/jmv.26117. Epub ahead of print. PMID: 32492200; PMCID: PMC7300640. - Giamarellos-Bourboulis EJ, Netea MG, Rovina N, Akinosoglou K, Antoniadou A,
Antonakos N, Damoraki G, Gkavogianni T, Adami ME, Katsaounou P, Ntaganou M,
Kyriakopoulou M, Dimopoulos G, Koutsodimitropoulos I, Velissaris D, Koufargyris
P, Karageorgos A, Katrini K, Lekakis V, Lupse M, Kotsaki A, Renieris G,
Theodoulou D, Panou V, Koukaki E, Koulouris N, Gogos C, Koutsoukou A. Complex
Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure. Cell
Host Microbe. 2020 Jun 10;27(6):992-1000.e3. doi: 10.1016/j.chom.2020.04.009.
Epub 2020 Apr 21. PMID: 32320677; PMCID: PMC7172841. - Akinosoglou K, deLastic AL, Niarou V, Ziazias D, Davoulos C, Kolosaka M,
Kosmopoulou F, Theodoraki S, Koutsouri CP, Gogos C. Could the Quick Sequential
Organ Failure Assessment Predictive Accuracy Be Affected by Site of Infection?
Am J Respir Crit Care Med. 2020 Jul 1;202(1):153-154. doi:
10.1164/rccm.202003-0552LE. PMID: 32250647; PMCID: PMC7328318. - Assimakopoulos SF, Akinosoglou K, de Lastic AL, Skintzi A, Mouzaki A, Gogos
CA. The Prognostic Value of Endotoxemia and Intestinal Barrier Biomarker ZO-1 in
Bacteremic Sepsis. Am J Med Sci. 2020 Feb;359(2):100-107. doi:
10.1016/j.amjms.2019.10.006. Epub 2019 Oct 22. PMID: 31812215. - Kyriazopoulou E, Sinapidis D, Halvatzis S, Velissaris D, Alexiou N, Kosmas
V, Adami ME, Kyprianou M, Kyprianou A, Stefos A, Lada M, Koutoukas P, Pavlaki M,
Kyriakoudi A, Makina A, Gogos C, Niederman MS, Giamarellos-Bourboulis EJ.
Survival benefit associated with clarithromycin in severe community-acquired
pneumonia: A matched comparator study. Int J Antimicrob Agents. 2020
Jan;55(1):105836. doi: 10.1016/j.ijantimicag.2019.10.017. Epub 2019 Nov 5. PMID:
31704213. - Pantazis N, Papastamopoulos V, Paparizos V, Metallidis S, Adamis G,
Antoniadou A, Psichogiou M, Chini M, Sambatakou H, Sipsas NV, Gogos C, Chrysos
G, Panagopoulos P, Katsarou O, Gikas A, Touloumi G; AMACS. Long-term evolution
of CD4+ cell count in patients under combined antiretroviral therapy. AIDS. 2019
Aug 1;33(10):1645-1655. doi: 10.1097/QAD.0000000000002248. PMID: 31305332. - Assimakopoulos SF, Triantos C, Thomopoulos K, Fligou F, Maroulis I, Marangos
M, Gogos CA. Gut-origin sepsis in the critically ill patient: pathophysiology
and treatment. Infection. 2018 Dec;46(6):751-760. doi:
10.1007/s15010-018-1178-5. Epub 2018 Jul 12. PMID: 30003491. - Assimakopoulos SF, Triantos C, Maroulis I, Gogos C. The Role of the Gut
Barrier Function in Health and Disease. Gastroenterology Res. 2018
Aug;11(4):261-263. doi: 10.14740/gr1053w. Epub 2018 Feb 8. PMID: 30116424;
PMCID: PMC6089582. - Pantazis N, Chini M, Antoniadou A, Sambatakou H, Skoutelis A, Gargalianos P,
Kourkounti S, Gogos C, Chrysos G, Psichogiou M, Sipsas NV, Katsarou O,
Panagopoulos P, Metallidis S, Touloumi G; AMACS. The HIV patient profile in 2013
and 2003: Results from the Greek AMACS cohort. PLoS One. 2018 Sep
12;13(9):e0203601. doi: 10.1371/journal.pone.0203601. PMID: 30208097; PMCID:
PMC6135491. - Velissaris D, Pierrakos C, Karamouzos V, Pantzaris ND, Gogos C. The use of
soluble urokinase plasminogen activator receptor (suPAR) as a marker of sepsis
in the emergency department setting. A current review. Acta Clin Belg. 2019 Aug
21:1-6. doi: 10.1080/17843286.2019.1653519. Epub ahead of print. PMID: 31434557. - Nodaras C, Kotsaki A, Tziolos N, Kontopoulou T, Akinosoglou K,
Chrisanthakopoulou M, Kranidioti E, Kritselis I, Voloudakis N, Vittoros V,
Gogkou A, Fillas I, Toutouzas KG, Bristianou M, Tsoutsos D, Christaki E, Adamis
G, Kaziani K, Tsironis C, Lada M, Kokkinakis E, Sympardi S, Koutelidakis IM,
Karkamanis A, Pantazi A, Bayram C, Alexiou Z, Mousoulis G, Gogos C, O'Hare M,
Griffiths D, MacGowan A, Sambatakou H, Giamarellos-Bourboulis EJ. Microbiology
of acute bacterial skin and skin-structure infections in Greece: A proposed
clinical prediction score for the causative pathogen. Int J Antimicrob Agents.
2019 Dec;54(6):750-756. doi: 10.1016/j.ijantimicag.2019.08.020. Epub 2019 Aug
31. PMID: 31479742. - Touloumi G, Kalpourtzi N, Papastamopoulos V, Paparizos V, Adamis G,
Antoniadou A, Chini M, Karakosta A, Makrilakis K, Gavana M, Vantarakis A,
Psichogiou M, Metallidis S, Sipsas NV, Sambatakou H, Hadjichristodoulou C,
Voulgari PV, Chrysos G, Gogos C, Chlouverakis G, Tripsianis G, Alamanos Y,
Stergiou G; AMACS and EMENO. Cardiovascular risk factors in HIV infected
individuals: Comparison with general adult control population in Greece. PLoS
One. 2020 Mar 30;15(3):e0230730. doi: 10.1371/journal.pone.0230730. PMID:
32226048; PMCID: PMC7105103. - Assimakopoulos SF, Papadopoulou I, Bantouna D, de Lastic AL, Rodi M, Mouzaki
A, Gogos CA, Zolota V, Maroulis I. Fecal Microbiota Transplantation and
Hydrocortisone Ameliorate Intestinal Barrier Dysfunction and Improve Survival in
a Rat Model of Cecal Ligation and Puncture-Induced Sepsis. Shock. 2020 Jun 2.
doi: 10.1097/SHK.0000000000001566. Epub ahead of print. PMID: 32496421.
